Imaging of White Matter Diseases – What Radiologists need to know!

Topics covered:

• Normal myelination.
• Hypoxic Ishemic Encephalopathy.
• Dysmelinating and demyelinating disorders.
• Approach to dysmyelinating disorders depending on
  • Involvement of grey matter / white matter or both
  • Central/ Peripheral involvement.
  • Enhancement pattern
  • Symmetrical involvement.
  • Head size.
  • Systemic involvement.
• Important disorders are covered with typical imaging findings.
• Check out the Atlas of normal myelination in neonates on our anatomy page.
• Go through this excellent Imaging flowchart from the AJR article titled 

Click here to to read an  excellent presentation on Normal Myelination by Fang Yu 1 M.D., Michael Wang 1 M.D., Kiran Sargar 2 M.D., Yutaka Sato 3 M.D., Achint K. Singh 1 M.D. 1: University of Texas Health Science Center San Antonio.

Resources:

1. Normal MR Imaging Anatomy of Brain.
2. AJR : Inborn Errors of Metabolism: Combining Clinical and Radiologic Clues to Solve the Mystery
3. RSNA :  Leukodystrophy in Children A Pictorial Review of MR Imaging Features.
4. Barkovich Pediatric Neuroimaging

About the Author

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Dr. Amar Udare, MD, DNB

Dr. Amar Udare is a board-certified radiologist. He is currently working as a fellow radiologist at McMaster University, Canada. He has a passion for teaching (#FOAMrad and #FOAMed) and has been a semi-finalist for the 2018 and 2020 Aunt-Minnie Most effective Radiology Educator Awards. He has authored multiple peer-reviewed publications which can be accessed on PubMed and Google Scholar.