Imaging of White Matter Diseases – What Radiologists need to know!

Alexanders disease Radiology
Alexanders disease MRI

Topics covered:

  • Normal myelination.
  • Hypoxic Ishemic Encephalopathy.
  • Dysmelinating and demyelinating disorders.
  • Approach to dysmyelinating disorders depending on
    • Involvement of grey matter / white matter or both
    • Central/ Peripheral involvement.
    • Enhancement pattern
    • Symmetrical involvement.
    • Head size.
    • Systemic involvement.
  • Important disorders are covered with typical imaging findings.
  • Check out the Atlas of normal myelination in neonates on our anatomy page.
  • Go through this excellent Imaging flowchart from the AJR article titled here.

Click here to to read an  excellent presentation on Normal Myelination by Fang Yu 1 M.D., Michael Wang 1 M.D., Kiran Sargar 2 M.D., Yutaka Sato 3 M.D., Achint K. Singh 1 M.D. 1: University of Texas Health Science Center San Antonio.

Resources:

  1. Normal MR Imaging Anatomy of Brain.
  2. AJR : Inborn Errors of Metabolism: Combining Clinical and Radiologic Clues to Solve the Mystery
  3. RSNA :  Leukodystrophy in Children A Pictorial Review of MR Imaging Features.
  4. Barkovich Pediatric Neuroimaging

Last Updated on June 3, 2020

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About the Author


Dr. Amar Udare, MD, DNB

Dr Amar UdareDr. Amar Udare is a board-certified radiologist. He is currently working as a fellow radiologist at McMaster University, Canada. He has a passion for teaching (#FOAMrad and #FOAMed) and has been a semi-finalist for the 2018 and 2020 Aunt-Minnie Most effective Radiology Educator Awards. He has authored multiple peer-reviewed publications which can be accessed on PubMed and Google Scholar.

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