A ranula is a collection of saliva in the floor of the mouth that comes from the sublingual gland. Most are not true cysts at all: the gland or its ducts are disrupted, mucus leaks into the surrounding tissue and walls itself off, so the lesion is a mucus extravasation pseudocyst with no epithelial lining. When the collection stays above the mylohyoid muscle it is a simple (oral, sublingual) ranula. When it reaches the submandibular space it is a plunging (diving, cervical) ranula.
On imaging the lesion itself is easy: a thin-walled, unilocular, fluid-density or fluid-signal collection that does not enhance unless it is infected. The two things that actually change what happens to the patient are harder, and they are what your report should settle. First, does the collection cross the mylohyoid sling, because that is what separates a simple from a plunging ranula. Second, is the sublingual gland involved, because removing that gland is the step that stops the lesion coming back, and recurrence after treatment that leaves the gland in place runs at 15 to 30 percent.
| At a glance | |
|---|---|
| What it is | Extravasated saliva from the sublingual gland, walled off as a pseudocyst; a true epithelium-lined retention cyst is the minority |
| Origin | Sublingual gland almost always; minor salivary glands of the floor of the mouth occasionally |
| Simple (oral) ranula | Confined to the sublingual space, above the mylohyoid muscle |
| Plunging (diving) ranula | Extends into the submandibular space, usually through a defect in the mylohyoid muscle |
| Relative frequency | About 4 in 5 are oral and 1 in 5 plunging in a 207-lesion ultrasound series |
| Typical patient | Second and third decades; children are common; equal sex distribution |
| Trigger | Blunt trauma to the floor of the mouth or neck, dental or oral surgery, or no identifiable cause |
| First-line imaging | Ultrasound. CT or MRI to map extent, to reach the deep margin, or when an epidermoid is in the differential |
| Signature CT or MRI finding | Tail sign: a thin collapsed band of the collection tracking back into the sublingual space. Useful when present, absent in most cases |
| Content on aspiration | Viscous, straw-coloured, amylase-rich mucus. Aspiration alone is not treatment |
| Definitive treatment | Transoral excision of the sublingual gland, complete rather than partial |
| Malignant potential | None |

Quiz
Which of the following is TRUE with regards to a ranula?
- Can undergo malignant transformation
- Most commonly congenital in etiology
- Arises from the sublingual or minor salivary glands
- Cyst aspiration is the treatment of choice
What is a ranula?
Two mechanisms are described, and the distinction matters because it explains why some treatments fail. In the retention cyst, a sublingual duct is obstructed and the duct dilates behind the obstruction, so the wall is lined by epithelium and the lesion is a true cyst. In the extravasation pseudocyst, the gland or duct is torn, saliva escapes into the connective tissue and a wall of granulation tissue and compressed fibrous tissue forms around it, so there is no epithelial lining at all. Quick and Lowell separated these two varieties in 1977 and the extravasation pseudocyst is the common one in practice, for both oral and plunging lesions.
The consequence is practical. You cannot cure a pseudocyst by removing its wall, because the wall is not the problem: the leaking gland is. That is why marsupialisation and aspiration recur, why excising the cyst without the gland recurs, and why every current series converges on taking out the sublingual gland itself.
The old teaching that a simple ranula is a true cyst while only a plunging ranula is a pseudocyst is a convenient shorthand rather than a histological rule. Treat both as extravasation phenomena unless pathology says otherwise.
| Simple (oral, sublingual) ranula | Plunging (diving, cervical) ranula | |
|---|---|---|
| Compartment | Sublingual space only, above the mylohyoid muscle | Submandibular space, with or without a residual sublingual component |
| Route | Does not cross the mylohyoid sling | Through a defect in the mylohyoid muscle in about 88 percent, around its posterior free edge in about 12 percent |
| Clinical appearance | Bluish, translucent swelling in the floor of the mouth, often unilateral and paramedian | Painless soft submandibular or upper cervical mass, frequently with nothing visible in the mouth |
| Relative frequency | About 82 percent of ranulas | About 18 percent of ranulas |
| Histology | Extravasation pseudocyst in most; retention cyst in the minority | Extravasation pseudocyst, essentially always |
| Shape on CT | Lenticular when unilateral, horseshoe-shaped when it crosses the midline | Larger and more irregular, comet or teardrop shaped with the bulk below the mylohyoid |
| Relation to submandibular gland | Not applicable | Sits medial and anterior to the gland and displaces it laterally and posteriorly |
| Definitive operation | Transoral excision of the sublingual gland | Transoral excision of the sublingual gland, with simple drainage of the cervical collection |
The anatomy that makes a ranula plunge
The mylohyoid muscle is the floor of the mouth. It slings from the mylohyoid line of the mandible to the hyoid bone and separates the sublingual space above it from the submandibular space below and lateral to it. The sublingual space is bounded anteriorly by the mandible, medially by the genioglossus and geniohyoid complex, inferolaterally by the mylohyoid and superomedially by the mucosa of the floor of the mouth. It contains the sublingual gland and duct, the deep part of the submandibular gland and Wharton duct, the lingual artery and vein, the lingual nerve and branches of cranial nerves IX and XII. Right and left sublingual spaces communicate anteriorly under the frenulum, which is why some ranulas are horseshoe-shaped.
The two spaces are continuous around the posterior free margin of the mylohyoid, and that was the traditional explanation for how a ranula plunges. It is not the usual route. The mylohyoid is commonly deficient: a fissure or oval opening, the mylohyoid boutonniere, through which sublingual gland and fat herniate. Nathan and Luchansky found such a deficiency in 82 of 300 dissected half-heads (27.3 percent), bilateral in 11.3 percent of cadavers. Harrison and colleagues found a hiatus with an associated hernia in 10 of 23 cadavers, and the hernia contained sublingual gland in 9 of them, which is the anatomical argument for taking out the sublingual gland rather than the submandibular gland.
Lee and colleagues then showed the same thing on CT in 41 plunging ranulas. Thirty-six (88 percent) took the anterior shortcut directly through a mylohyoid defect, most often in the anterior third of the muscle, and the sublingual gland was partly herniated through the defect in 30 of them. Only 5 (12 percent) travelled around the posterior free edge. The submandibular space was involved in every single case.

Ranula on ultrasound, CT and MRI
Start with ultrasound. In the largest series, 207 ranulas scanned over 20 years, the lesion was hypoechoic to anechoic in 97.6 percent, was always in close relationship to the sublingual gland and the mylohyoid muscle, and ultrasound depicted the exact plunging pattern in every plunging lesion. Palpating the floor of the mouth and the submandibular region while scanning, described as sonopalpation, has been reported to make the relationship between the sublingual gland, the fluid and the mylohyoid dehiscence easier to see, although only in a three-patient proof-of-concept series. Ultrasound will not reach a large retropharyngeal or parapharyngeal extension, so cross-sectional imaging follows when the lesion is big, recurrent or preoperative.
| Modality | Simple ranula | Plunging ranula | Infected ranula |
|---|---|---|---|
| Ultrasound | Thin-walled anechoic or hypoechoic collection in the sublingual space, in contact with the sublingual gland, no internal vascularity | Irregular collection extending below the level of the mylohyoid; the defect and the herniated gland can usually be shown directly | Thickened wall, internal echoes and debris, increased peripheral flow |
| CT (contrast-enhanced) | Well-defined unilocular low-attenuation cyst, lenticular if unilateral and horseshoe-shaped if it crosses the midline, thin or no wall enhancement | Comet or teardrop-shaped collection filling the submandibular space, displacing the submandibular gland laterally, with or without a tail back into the sublingual space | Thick enhancing wall, higher attenuation contents, adjacent fat stranding |
| MRI | T1 hypointense to intermediate (signal rises with protein content), T2 hyperintense, thin non-enhancing wall, no restricted diffusion | Coronal and axial T2 fat-suppressed images show the tail and the exact level of the mylohyoid best | Higher T1 signal, T2 heterogeneity, thick enhancing wall, surrounding oedema |
| Diffusion-weighted imaging | No restricted diffusion. This is what separates a ranula from an epidermoid cyst, which restricts | Same | May restrict because of pus, so interpret with the wall enhancement |
The tail sign, and how far to trust it
When a ranula herniates, the part left behind in the sublingual space is squeezed into a thin band that points back towards the sublingual gland. That band is the tail sign, and the whole lesion is then described as comet-shaped, with the body in the submandibular space and the tail in the sublingual space. Finding it is close to diagnostic, because it tells you the collection came from above the mylohyoid and therefore from the sublingual gland.
A tail you cannot see, though, proves nothing. In the Lee CT series the tail sign was present in only 14 of 41 plunging ranulas, about a third: in the remaining 22 lesions that went through a mylohyoid defect, the sublingual component had emptied completely into the neck and left no tail behind. Reporting a submandibular cystic mass as “not a ranula because there is no tail sign” is therefore a mistake. Look instead for the mylohyoid defect itself, the herniated sublingual gland and the absence of a normal fat plane between the collection and the gland.
Reporting checklist
- Compartment: sublingual space only, or does the collection cross the level of the mylohyoid muscle.
- Route, if it crosses: through a mylohyoid defect (name the third of the muscle) or around the posterior free margin.
- Sublingual gland: normal, partly herniated through the defect, or effaced by the collection. Say which side.
- Tail sign: present or absent. State that its absence does not exclude a plunging ranula.
- Submandibular gland: displaced but normal, versus intrinsically abnormal, and state the direction of displacement.
- Extent: parapharyngeal, retropharyngeal, tongue base, vallecula or infrahyoid extension, and the distance from the airway.
- Complicating features: wall thickening, enhancement, internal debris, surrounding fat stranding, or airway narrowing.
- Alternatives considered and why they are out: restricted diffusion would favour an epidermoid, fat globules a dermoid, septations and fluid-fluid levels a lymphatic malformation, a calculus or a dilated Wharton duct submandibular obstruction.
Differential diagnosis of a cystic mass in the floor of the mouth
| Lesion | What tells it apart | Compartment |
|---|---|---|
| Epidermoid cyst | Restricted diffusion on DWI with low ADC. On CT and ultrasound it can be identical to a ranula, so DWI is the discriminator | Floor of mouth, often midline |
| Dermoid cyst | Fat globules floating in fluid, the sack of marbles appearance; fat attenuation on CT and high T1 signal | Midline floor of mouth, submental |
| Lymphatic malformation | Multiloculated and septated, fluid-fluid levels, insinuates across compartments rather than respecting one, thin peripheral enhancement | Trans-spatial |
| Second branchial cleft cyst | Centred at the angle of the mandible along the anterior border of sternocleidomastoid, posterolateral to the submandibular gland, no relationship to the sublingual gland and no tail | Posterior submandibular space and carotid space |
| Thyroglossal duct cyst | Midline or paramedian, embedded in or abutting the strap muscles, at or below the hyoid, tract towards the foramen caecum | Midline, infrahyoid more often than suprahyoid |
| Submandibular sialadenitis with obstruction | The gland itself is enlarged and enhancing, with a calculus and a dilated Wharton duct; the fluid is intraglandular or ductal, not a separate walled-off collection | Submandibular gland and duct |
| Abscess (including Ludwig angina) | Thick enhancing rim, restricted diffusion, gas, fat stranding, systemic sepsis and pain. A ranula can become infected and look like this | Sublingual, submandibular, often bilateral |
| Venous or venolymphatic malformation | Phleboliths, gradual filling on delayed images, changes with Valsalva or position | Trans-spatial |
| Cystic or necrotic node, cystic metastasis | Nodal location with a thick irregular wall; look for a primary in the oropharynx or thyroid | Submandibular, level I to II |
| Simple lingual or floor-of-mouth mucocele | Much smaller, superficial and submucosal, arising from a minor salivary gland rather than the sublingual gland; no relationship to the mylohyoid | Submucosal, floor of mouth or ventral tongue |
Clinical features and who gets a ranula
- Simple ranula: a painless bluish translucent swelling in the floor of the mouth. Large lesions push the tongue up and interfere with speech, chewing and denture fit.
- Plunging ranula: a soft, painless, non-tender submandibular or upper cervical swelling. The floor of the mouth is often completely normal, which is exactly why these are sent for imaging as an undiagnosed neck mass.
- Age and sex: most present in the second and third decades. In one series of 20 plunging ranulas the median age was 31 with 11 men and 9 women. Congenital cases occur but are rare.
- Trauma: a clear history of blunt injury to the floor of the mouth or neck, or of dental or oral surgery, is present in a minority. Ranulas are also reported as a late complication of tongue cancer resection.
- Ethnicity: plunging ranulas are markedly over-represented in Maori and Pacific Island Polynesian populations. Whether this reflects a higher rate of mylohyoid dehiscence is unknown.
- Aspirate: viscous, straw-coloured, amylase-rich and protein-rich mucus. An amylase-rich aspirate from a submandibular cystic mass is strong supporting evidence, but it is not treatment.
- Malignant potential: none. A ranula does not transform.
What the surgeon does with your report
Every treatment for a ranula is an attempt to stop saliva escaping from the sublingual gland. They differ in how completely they achieve that, and the recurrence figures follow directly. The most recent systematic review, 71 studies and 809 patients, found that excision including the ipsilateral sublingual gland kept recurrence below 10 percent, while anything that left the gland behind ran at 15 to 30 percent. Most recurrences declare themselves within 3 to 6 months.
| Treatment | What it does | Reported recurrence | Comment |
|---|---|---|---|
| Transoral excision of the sublingual gland | Removes the source of the leak | Under 10 percent | The reference treatment for both oral and plunging ranula. Complete excision beat partial excision 0 of 22 versus 5 of 20 in a comparative series |
| Transcervical excision | Removes the cervical collection, with or without the gland | Similar cure rate to the transoral route when the gland is taken | Higher morbidity than transoral in pooled data; lingual nerve injury is the main risk |
| Excision of the cyst without the gland | Removes the wall, not the source | 15 to 30 percent | Illogical for a pseudocyst and the numbers show it |
| Marsupialisation | Creates a drainage tract into the mouth | 15 to 30 percent | Simple and low-morbidity; micromarsupialisation performs better than classical marsupialisation in pooled series |
| Bleomycin sclerotherapy | Induces fibrosis and seals the leak | 3 to 10 percent | The best-performing sclerosant in the pooled data |
| OK-432 (picibanil) sclerotherapy | Immune-mediated sclerosis | Good for oral lesions, over 50 percent for plunging lesions | In a randomised placebo-controlled trial every intraoral ranula resolved completely but only 1 of 4 plunging ranulas did |
| Polidocanol foam sclerotherapy | Detergent sclerosant, low toxicity | 4 of 34 unfavourable outcomes, so about 88 percent complete resolution | Newer option for sublingual ranula; larger lesions did worse |
| Aspiration alone | Removes the fluid only | Highest of all | Diagnostic at best. Not a treatment |
Read that last line carefully before you write a management sentence into a report. The direction of travel in the literature is consistent, and sublingual gland excision is the defensible default, but the evidence base is retrospective and no randomised comparison of the surgical options exists. Describe the anatomy precisely and leave the choice of operation to the surgeon.
Why it is called a ranula
“Ranula” is the diminutive of the Latin rana, a frog. The bluish translucent bulge lifting the mucosa of the floor of the mouth was thought to resemble the inflated vocal sac of a frog. The synonyms follow the anatomy rather than the amphibian: oral or sublingual ranula for the lesion confined above the mylohyoid, and plunging, diving or cervical ranula for the one that reaches the neck.

Frequently asked questions
References
Single best review article
- Patel S, Bhatt AA. Imaging of the sublingual and submandibular spaces. Insights Imaging. 2018;9(3):391-401. PMID: 29675626. Open access, and the best single account of the anatomy and the cystic differential.
Imaging and anatomy
- Coit WE, Harnsberger HR, Osborn AG, Smoker WR, Stevens MH, Lufkin RB. Ranulas and their mimics: CT evaluation. Radiology. 1987;163(1):211-216. PMID: 3823437.
- Lee JY, Lee HY, Kim HJ, et al. Plunging ranulas revisited: a CT study with emphasis on a defect of the mylohyoid muscle as the primary route of lesion propagation. Korean J Radiol. 2016;17(2):264-270. PMID: 26957912.
- Koch M, Mantsopoulos K, Leibl V, Muller S, Iro H, Sievert M. Ultrasound in the diagnosis and differential diagnosis of enoral and plunging ranula: a detailed and comparative analysis. J Ultrasound. 2023;26(2):487-495. PMID: 36527568.
- Molotkova E, Maley J, Hoffman H. Sonopalpation for ultrasound evaluation of plunging ranula. Ear Nose Throat J. 2025 Jul 28 (online ahead of print). PMID: 40719167.
- Nathan H, Luchansky E. Sublingual gland herniation through the mylohyoid muscle. Oral Surg Oral Med Oral Pathol. 1985;59(1):21-23. PMID: 3856203.
- Harrison JD, Kim A, Al-Ali S, Morton RP. Postmortem investigation of mylohyoid hiatus and hernia: aetiological factors of plunging ranula. Clin Anat. 2013;26(6):693-699. PMID: 23355334.
Pathogenesis, clinical series and treatment
- Quick CA, Lowell SH. Ranula and the sublingual salivary glands. Arch Otolaryngol. 1977;103(7):397-400. PMID: 880105.
- Davison MJ, Morton RP, McIvor NP. Plunging ranula: clinical observations. Head Neck. 1998;20(1):63-68. PMID: 9464954.
- Nguyen K, Goodman E, Vibhute M, Blake L, Richter GT, Kompelli A. Systematic review and meta-analysis of the management and outcomes of recurrent ranulas. Oral Dis. 2026;32(7):1816-1827. PMID: 41841403.
- Souza MRF, Goncalves MWA, Martins-Chaves RR, et al. Treatments to avoid ranula recurrence: a network meta-analysis. J Oral Pathol Med. 2025;54(10):934-943. PMID: 40921455.
- Chung YS, Cho Y, Kim BH. Comparison of outcomes of treatment for ranula: a proportion meta-analysis. Br J Oral Maxillofac Surg. 2019;57(7):620-626. PMID: 31239229.
- Roh JL. Transoral complete vs partial excision of the sublingual gland for plunging ranula. Otolaryngol Head Neck Surg. 2022;167(3):479-483. PMID: 34932413.
- Wendt M, Papatziamos G, Munck-Wikland E, Marklund L. Sclerotherapy of ranulas with OK-432: a prospective, randomized, double-blinded placebo-controlled study. Acta Otolaryngol. 2021;141(5):531-536. PMID: 33775200.
- Li K, Yang X, Yu C, Zheng J, Du G, Zhou Q. Clinical outcomes of polidocanol foam sclerotherapy in treatment of sublingual ranula. Int Dent J. 2026;76(3):109512. PMID: 41861582.
- Gontarz M, Bargiel J, Gasiorowski K, et al. Surgical treatment of sublingual gland ranulas. Int Arch Otorhinolaryngol. 2023;27(2):e296-e301. PMID: 37125362.
Related reading on RadioGyan: benign lymphoepithelial cysts of the parotid gland for the other common cystic salivary lesion, the sack of marbles sign for the dermoid that sits in the same differential, and retropharyngeal versus parapharyngeal abscess for the deep neck spaces a large plunging ranula can reach.
Original case and illustrations: Dr. Disha Lokhandwala. Co-author: Dr. Mansi Sarmalkar. Reviewed, rewritten and expanded in 2026.
