What causes ring-around-artery sign in hands on hand radiographs?
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Answer:
Peri-arterial calcification manifesting as circumferential calcific rings around radial and digital arteries in primary hyperparathyroidism or longstanding diabetes mellitus.
This finding is known as the ring-around-artery sign on hand radiographs.
Why is it called so?
The name describes the ring-like calcification encircling the artery, resembling a halo or ring around the vessel lumen on radiography.
Pathophysiology
In primary hyperparathyroidism, excess parathyroid hormone induces hypercalcemia and metastatic calcification due to elevated calcium-phosphate product; in diabetes, chronic hyperglycemia promotes medial vascular calcification via advanced glycation end-products and osteogenic transdifferentiation of smooth muscle cells, leading to peri-arterial deposition visible on plain films.
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